predicting the impact of human missense variants
based on proteins' sequence, structure and dynamics
In silico saturation mutagenesis
perform a complete scan of all possible 19 amino acid substitutions at each site on a human sequence. See example: H-Ras.
Variants on custom PDB structure
perform saturation mutagenesis analysis on a specific conformer, homology model or homologous structure (in case human structure is not available).
Batch query of individual variants
obtain predictions for a batch of up to 10,000 individual human missense variants from various protein sequences. See an example here.